AMOT and PTPA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		AMOT	PTPA
Description		angiomotin	protein phosphatase 2 phosphatase activator
Image
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction External Side Of Plasma Membrane Lamellipodium Cell Junction Endocytic Vesicle Cytoplasmic Vesicle	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity Angiostatin Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity ATP Hydrolysis Activity Protein Phosphatase Regulator Activity Protein Homodimerization Activity Protein Phosphatase 2A Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Blood Vessel Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction	Protein Peptidyl-prolyl Isomerization Mitotic Spindle Organization Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Drugs
Diseases
GWAS
Interacting Genes		57 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LURAP1 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NTAQ1 NUFIP2 PBLD PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UNC119	29 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SPG21 SRC SULT4A1 TSC1
Entrez ID		154796	5524
HPRD ID		02327	02858
Ensembl ID		ENSG00000126016	ENSG00000119383
Uniprot IDs		Q4VCS5	B4DZF8 F6WIT2 Q15257
PDB IDs		6JJX	2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?
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