KLB and FGF21

Number of citations of the paper that reports this interaction (PubMedID 19059246)
49

Data Source:
HPRD (in vitro)

		KLB	FGF21
Description		klotho beta	fibroblast growth factor 21
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Fibroblast Growth Factor Receptor Binding Protein Binding Fibroblast Growth Factor Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Carbohydrate Metabolic Process Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway	Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Triglyceride Catabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Cell Differentiation Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Positive Regulation Of Glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Xenobiotic Stimulus Endothelial Cell Apoptotic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Methionine Positive Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Cellular hexose transport Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinks per week) ( 28485404 30643258 31959922 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder (consumption score) ( 30940813 30336701 33861876) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Asthma ( 30929738) Asthma (adult onset) ( 30929738) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Urate levels ( 31578528)	Bipolar disorder ( 21926972) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Cooked vegetable consumption ( 32066663) Dietary macronutrient intake ( 23372041 23636237 29988085) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pancreas volume ( 34128465) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Relative carbohydrate intake ( 32393786) Relative protein intake ( 32393786) Relative sugar intake ( 32393786) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Urinary sodium excretion ( 31409800)
Interacting Genes		2 interacting genes: FGF21 FGFR1	9 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 SGTA SGTB TNS2 YPEL3
Entrez ID		152831	26291
HPRD ID		14097	09447
Ensembl ID		ENSG00000134962	ENSG00000105550
Uniprot IDs		B4DYH5 Q86Z14	Q9NSA1
PDB IDs		5VAK 5VAN 5VAQ 5WI9 6NFJ	5VAQ 6M6E 6M6F
Enriched GO Terms of Interacting Partners?
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