FGF21 and CDH7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		FGF21	CDH7
Description		fibroblast growth factor 21	cadherin 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Plasma Membrane Adherens Junction Integral Component Of Membrane Catenin Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Calcium Ion Binding Cadherin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Triglyceride Catabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Cell Differentiation Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Positive Regulation Of Glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Xenobiotic Stimulus Endothelial Cell Apoptotic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Methionine Positive Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Endothelial Cell Apoptotic Process	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Cellular hexose transport Assembly of active LPL and LIPC lipase complexes	Adherens junctions interactions
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Cooked vegetable consumption ( 32066663) Dietary macronutrient intake ( 23372041 23636237 29988085) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pancreas volume ( 34128465) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Relative carbohydrate intake ( 32393786) Relative protein intake ( 32393786) Relative sugar intake ( 32393786) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Urinary sodium excretion ( 31409800)	Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Body mass index ( 28892062) Cardiac Troponin-T levels ( 23247143) Fractional excretion of metabolites in chronic kidney disease ( 29545352) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Irritable mood ( 29500382) Metabolite levels ( 23823483) Prudent dietary pattern ( 28644415)
Interacting Genes		9 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 SGTA SGTB TNS2 YPEL3	6 interacting genes: CDH12 CDH15 CDH6 CDH9 CTNNB1 FGF21
Entrez ID		26291	1005
HPRD ID		09447	12049
Ensembl ID		ENSG00000105550	ENSG00000081138
Uniprot IDs		Q9NSA1	F5H5X9 Q8IY78 Q9ULB5
PDB IDs		5VAQ 6M6E 6M6F
Enriched GO Terms of Interacting Partners?
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