VCAN and PF4

Number of citations of the paper that reports this interaction (PubMedID 11083865)
65

Data Source:
BioGRID (pull down)

		VCAN	PF4
Description		versican	platelet factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Symbiont-containing Vacuole Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Cell Adhesion Multicellular Organism Development Central Nervous System Development Cell Recognition	Inflammatory Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Leukocyte Chemotaxis Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation	Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Hyaluronic acid	Drotrecogin alfa Heparin
Diseases
GWAS		Appendicular lean mass ( 28724990) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness (mean) ( 31801372) Cortical surface area (MOSTest) ( 32665545) Cortical volume ( 32963231) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Joint mobility (Beighton score) ( 27182965) Laryngeal squamous cell carcinoma ( 25194280) Lean body mass ( 28724990) Major depressive disorder ( 20516156) Optic disc size ( 31809533) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter hyperintensity volume ( 29752348 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter integrity (fractional anisotropy) ( 29752348 32358547) White matter integrity (mean diffusivity) ( 29752348 32358547)	Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1	28 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN XCL1 XCL2
Entrez ID		1462	5196
HPRD ID		00340	01426
Ensembl ID		ENSG00000038427	ENSG00000163737
Uniprot IDs		A0A024RAL1 A0A024RAP3 A0A024RAQ9 P13611 Q59FG9 Q6MZK8 Q86W61	P02776
PDB IDs			1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU
Enriched GO Terms of Interacting Partners?
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