PF4 and CCL5

Number of citations of the paper that reports this interaction (PubMedID 15459010)
97

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		PF4	CCL5
Description		platelet factor 4	C-C motif chemokine ligand 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Symbiont-containing Vacuole Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Phosphatidylinositol Phospholipase C Activity Protein Kinase Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Self-association Chemokine Receptor Antagonist Activity CCR Chemokine Receptor Binding
	Biological Process	Inflammatory Response Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Leukocyte Chemotaxis Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Defense Response To Protozoan Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Leukocyte Cell-cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Cellular Biosynthetic Process Activation Of Phospholipase D Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Protein Kinase B Signaling Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Protein Tyrosine Kinase Activity Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotaxis Cellular Response To Virus Regulation Of Neuron Death Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Chemokine receptors bind chemokines G alpha (i) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Drotrecogin alfa Heparin	Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Blood protein levels ( 30072576 28240269)
Interacting Genes		28 interacting genes: CCL11 CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN XCL1 XCL2	56 interacting genes: AATF ACKR1 ACKR2 ACKR4 APC BAG4 BCAR3 CCL11 CCL13 CCL16 CCL17 CCL2 CCL20 CCL21 CCL24 CCL25 CCL26 CCL27 CCL28 CCR1 CCR3 CCR4 CCR5 CHEK2 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 DPP4 EDC4 FZR1 GRB2 IGFBP7 KRAS PALB2 PF4 PHB PIGR PPBP PTPN1 RANGAP1 RELA SDC1 SDC4 SLC2A5 TGFB1 TRIP6 VCAN WT1 XCL1 XCL2
Entrez ID		5196	6352
HPRD ID		01426	01751
Ensembl ID		ENSG00000163737	ENSG00000271503
Uniprot IDs		P02776	A0A494C1Q1 D0EI67 P13501
PDB IDs		1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP 4R9W 4R9Y 4RAU	1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW 5CMD 5COY 5DNF 5L2U 5UIW 6AEZ 6C6D 6FGP 6LOG 6STK
Enriched GO Terms of Interacting Partners?
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