CSNK2A2 and FOS

Number of citations of the paper that reports this interaction (PubMedID 9685505)
8

Data Source:
HPRD (in vitro)

		CSNK2A2	FOS
Description		casein kinase 2 alpha 2	Fos proto-oncogene, AP-1 transcription factor subunit
Image
GO Annotations	Cellular Component	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol Membrane Protein-DNA Complex Transcription Factor AP-1 Complex Neuron Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Apoptotic Process Cell Cycle Spermatogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebral Cortex Development Regulation Of Cell Cycle Liver Regeneration Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Conditioned Taste Aversion DNA Methylation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Xenobiotic Stimulus Response To Light Stimulus Response To Gravity Response To Toxic Substance Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Immobilization Stress Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Positive Regulation Of Neuron Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ROS sensing by NFE2L2 Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib	Pseudoephedrine Nadroparin
Diseases
GWAS		Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)
Interacting Genes		107 interacting genes: ABCA1 ACACA ADH1A AMFR AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GOT2 GRIN2A GRIN2B GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP53 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF423 ZNF670 ZNHIT3	123 interacting genes: AKAP5 ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5ME BATF BCL3 CABP1 CARM1 CCDC120 CCND1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 DNMT3L DYNLT3 EEF1D ELK1 ELK4 ENKD1 EPHB2 ETS1 ETS2 FHL3 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HMGB1 HNF1A HSPA1A JUN JUNB JUND KDM2A KDM2B LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK3 MAPK7 MDM2 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PIN1 PML POLR2E PRKAA2 PRKACA PRKAR2A PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TENT5B TP53 TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133
Entrez ID		1459	2353
HPRD ID		00279	01275
Ensembl ID		ENSG00000070770	ENSG00000170345
Uniprot IDs		H3BNI9 P19784	P01100 Q6FG41
PDB IDs		3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU 7A1B 7A1Z 7A22 7A2H	1A02 1FOS 1S9K
Enriched GO Terms of Interacting Partners?
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