H1-1 and NSD3

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		H1-1	NSD3
Description		H1.1 linker histone, cluster member	nuclear receptor binding SET domain protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm
	Molecular Function	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific) Transcription Regulator Activator Activity
	Biological Process	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination	Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K36 Trimethylation
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Interacting Genes		52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	49 interacting genes: AKT1 AP3M2 ATM BCAR3 BMP8B CASP8 CBLC CBX3 CBX5 CDKN2A CHEK2 DAXX DOCK7 E2F5 ESR1 ETV3 ETV6 FGFR4 GLIS2 GLYR1 H1-1 H3-5 H3C1 H4C1 HOXC4 IVNS1ABP LSM1 MLLT6 MNDA MYC NFIC PAX2 PPM1D RB1CC1 SEPTIN6 SLU7 SOX3 SOX4 SPAG8 SQSTM1 STAC3 TCF3 TEAD2 TERT TGFB1 TRIM55 TRIM63 UBE2I ZNF557
Entrez ID		3024	54904
HPRD ID		00820	06155
Ensembl ID		ENSG00000124610	ENSG00000147548
Uniprot IDs		Q02539	Q9BZ95
PDB IDs			2DAQ 2NCZ 2ND1 4GND 4GNE 4GNF 4GNG 4RXJ 5UPD 6CEN 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P 6G3T 7CRP 7CRQ 7CRR
Enriched GO Terms of Interacting Partners?
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