DNAAF6 and P2RX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		DNAAF6	P2RX4
Description		dynein axonemal assembly factor 6	purinergic receptor P2X 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Trans-Golgi Network	Integral Component Of Nuclear Inner Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Dynein Intermediate Chain Binding Chaperone Binding	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity
	Biological Process	Cilium Movement Flagellated Sperm Motility Outer Dynein Arm Assembly Inner Dynein Arm Assembly Axonemal Dynein Complex Assembly	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Neuronal Action Potential Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Prostaglandin Secretion Response To ATP Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Regulation Of Ruffle Assembly Microglial Cell Migration Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis
Pathways			Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection
Drugs			Promethazine Eslicarbazepine acetate Eslicarbazepine
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Left ventricular obstructive tract defect (inherited effect) ( 28468790)
Interacting Genes		16 interacting genes: ARID4B BTAF1 CCAR1 CDKL3 GAS2L2 KAT5 KIF13A MCM7 P2RX4 PID1 POLDIP2 PRKAA2 QRICH1 RNF39 TSEN15 YAF2	10 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA USP16 WNT4
Entrez ID		139212	5025
HPRD ID		06650	09017
Ensembl ID		ENSG00000080572	ENSG00000135124
Uniprot IDs		Q9NQM4	Q99571
PDB IDs
Enriched GO Terms of Interacting Partners?
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