ATP6V1G3 and DENND1B

		ATP6V1G3	DENND1B
Description		ATPase H+ transporting V1 subunit G3	DENN domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex	Cytosol Nuclear Speck Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Proton Transmembrane Transport	Endocytosis Protein Transport Endocytic Recycling Positive Regulation Of GTPase Activity Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	RAB GEFs exchange GTP for GDP on RABs
Drugs		Tiludronic acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) ( 23648065) Asthma ( 31959851) Body mass index ( 28552196) General risk tolerance (MTAG) ( 30643258) Mean corpuscular hemoglobin ( 29403010 20139978) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Multiple sclerosis ( 31604244) Pulse pressure ( 33230300) Red blood cell count ( 29403010)	Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		3 interacting genes: DENND1B LMAN2L OTX2	5 interacting genes: ATP6V1G3 GLRX2 KCNT2 LNX1 ZBTB41
Entrez ID		127124	163486
HPRD ID		16526	13303
Ensembl ID		ENSG00000151418	ENSG00000213047
Uniprot IDs		Q96LB4	A0A024R987 Q6P3S1
PDB IDs			3TW8
Enriched GO Terms of Interacting Partners?
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