ABCC2 and AZIN1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ABCC2	AZIN1
Description		ATP binding cassette subfamily C member 2	antizyme inhibitor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus Intracellular Canaliculus	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Protein Domain Specific Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity	Ornithine Decarboxylase Activity Protein Binding Ornithine Decarboxylase Activator Activity
	Biological Process	Xenobiotic Transmembrane Transport Inflammatory Response Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Inorganic Anion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Bile Acid Signaling Pathway Heme Catabolic Process Xenobiotic Catabolic Process Response To Estrogen Xenobiotic Export Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Xenobiotic Stimulus Cellular Response To Dexamethasone Stimulus Leukotriene Transport Response To Antineoplastic Agent Regulation Of Bile Acid Secretion Transport Across Blood-brain Barrier Benzylpenicillin Metabolic Process Response To 17alpha-ethynylestradiol Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier	Putrescine Biosynthetic Process From Ornithine Negative Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Positive Regulation Of Polyamine Transmembrane Transport
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS	Regulation of ornithine decarboxylase (ODC)
Drugs		ATP Sulfinpyrazone
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum metabolite levels ( 33031748) Stent thrombosis in response to clopidogrel treatment ( 32472697)	Airway imaging phenotypes ( 26030696) Apolipoprotein A1 levels ( 32203549) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 27863252) PR interval ( 32439900) QT interval ( 24952745) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 28552196) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1	9 interacting genes: ABCC2 ADSS1 ARNTL CDKN2A FANCA FANCC KHDRBS1 OAZ3 SORCS3
Entrez ID		1244	51582
HPRD ID		03065	07443
Ensembl ID		ENSG00000023839	ENSG00000155096
Uniprot IDs		Q92887	A0A024R9C7 B3KTF6 O14977
PDB IDs			4ZGZ
Enriched GO Terms of Interacting Partners?
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