AGBL1 and SEC11A

		AGBL1	SEC11A
Description		AGBL carboxypeptidase 1	SEC11 homolog A, signal peptidase complex subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding Tubulin Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Proteolysis C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation	Signal Peptide Processing
Pathways		Carboxyterminal post-translational modifications of tubulin	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Acute lymphoblastic leukemia ( 33891562) Acute lymphoblastic leukemia (adult) ( 33891562) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) Coronary artery calcification ( 23870195) Cytomegalovirus antibody response ( 21993531) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Ischemic stroke ( 26089329) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Migraine ( 21448238) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Neurociticism ( 29500382) Neuroticism ( 29255261) Psychosis (methamphetamine induced) ( 23594818) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rostral middle frontal gyrus volume ( 31530798) Schizophrenia ( 18347602) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212) Triiodothyronine levels ( 30843173) Venous thromboembolism ( 33592630)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes		2 interacting genes: SEC11A ZNF592	15 interacting genes: ADAM33 AGBL1 BCHE CCL3 CCNDBP1 CEP76 CSNK2B KLHL25 LINC00052 NUPR1 OAZ2 PDE8A PDIA3 RAB27B SLC35F6
Entrez ID		123624	23478
HPRD ID		07115	07503
Ensembl ID		ENSG00000273540	ENSG00000140612
Uniprot IDs		Q96MI9	A0A024RC78 H0YKT4 P67812
PDB IDs
Enriched GO Terms of Interacting Partners?
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