SEC11A and ADAM33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SEC11A	ADAM33
Description		SEC11 homolog A, signal peptidase complex subunit	ADAM metallopeptidase domain 33
Image		No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Signal Peptide Processing	Proteolysis
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ADAM33 AGBL1 BCHE CCL3 CCNDBP1 CEP76 CSNK2B KLHL25 LINC00052 NUPR1 OAZ2 PDE8A PDIA3 RAB27B SLC35F6	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		23478	80332
HPRD ID		07503	06173
Ensembl ID		ENSG00000140612	ENSG00000149451
Uniprot IDs		A0A024RC78 H0YKT4 P67812	A2A2L3 Q9BZ11
PDB IDs			1R54 1R55
Enriched GO Terms of Interacting Partners?
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