TARS3 and ARPC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TARS3	ARPC3
Description		threonyl-tRNA synthetase 3	actin related protein 2/3 complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus Cytoplasm	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	Molecular_function Threonine-tRNA Ligase Activity Protein Binding ATP Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Threonyl-tRNA Aminoacylation Biological_process	Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		11 interacting genes: ARPC3 ARRDC4 ATF4 DNM1P46 ECSIT LGALS14 LRRC28 SELENOS TARS1 TARS2 TM2D3	32 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SRPK2 SYBU TARS3 THNSL2 WAS WASF2 WASHC4 WASL ZNF576
Entrez ID		123283	10094
HPRD ID		15469	09175
Ensembl ID		ENSG00000185418	ENSG00000111229
Uniprot IDs		A2RTX5	O15145
PDB IDs			6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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