SH2D1B and PRDX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SH2D1B	PRDX1
Description		SH2 domain containing 1B	peroxiredoxin 1
Image
GO Annotations	Cellular Component	Cytosol	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Identical Protein Binding Cadherin Binding
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Cellular Response To Stress Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Regulation Of NIK/NF-kappaB Signaling
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)
Interacting Genes		26 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 FCRLA GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	30 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR EXOSC3 GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		117157	5052
HPRD ID		12248	01458
Ensembl ID		ENSG00000198574	ENSG00000117450
Uniprot IDs		O14796	A0A384NPQ2 Q06830
PDB IDs		5KAZ	2RII 3HY2 4XCS
Enriched GO Terms of Interacting Partners?
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