MED8 and THOC7

Number of citations of the paper that reports this interaction (PubMedID 12584197)
22

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MED8	THOC7
Description		mediator complex subunit 8	THO complex 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mediator Complex Core Mediator Complex	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding	RNA Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination	MRNA Processing MRNA Export From Nucleus RNA Splicing Viral MRNA Export From Host Cell Nucleus
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Neutrophil count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49	11 interacting genes: CCDC146 CHD3 CKAP4 GOT2 MED22 MED8 MNS1 NDC80 NIF3L1 SMARCD1 THOC5
Entrez ID		112950	80145
HPRD ID		06991	17632
Ensembl ID		ENSG00000159479	ENSG00000163634
Uniprot IDs		Q96G25	A0A024R332 A0A5S6STF9 Q6I9Y2
PDB IDs			7APK
Enriched GO Terms of Interacting Partners?
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