AKAP11 and PRKAR2B

Number of citations of the paper that reports this interaction (PubMedID 10864471)
32

Data Source:
HPRD (in vivo)

		AKAP11	PRKAR2B
Description		A-kinase anchoring protein 11	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Renal Water Homeostasis Protein Localization Cortical Actin Cytoskeleton Organization Intracellular Signal Transduction Protein Localization To Endosome	Fatty Acid Metabolic Process Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Response To Clozapine Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740) Bone mineral density (spine) ( 19801982) Crohn's disease ( 28067908) Hepcidin levels ( 27846281) Inflammatory bowel disease ( 28067908) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Serum alkaline phosphatase levels ( 33547301 33339817) Type 1 diabetes ( 34012112 34127860)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		8 interacting genes: ENOX1 GSK3A GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B	26 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2
Entrez ID		11215	5577
HPRD ID		05261	01486
Ensembl ID		ENSG00000023516	ENSG00000005249
Uniprot IDs		Q9UKA4	A0A024R712 B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?
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