AKAP11 and ENOX1

		AKAP11	ENOX1
Description		A-kinase anchoring protein 11	ecto-NOX disulfide-thiol exchanger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane	Extracellular Space Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Nucleic Acid Binding Protein Disulfide Isomerase Activity NADH Dehydrogenase Activity Protein Binding Protein-disulfide Reductase Activity
	Biological Process	Renal Water Homeostasis Protein Localization Cortical Actin Cytoskeleton Organization Intracellular Signal Transduction Protein Localization To Endosome	Ultradian Rhythm
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740) Bone mineral density (spine) ( 19801982) Crohn's disease ( 28067908) Hepcidin levels ( 27846281) Inflammatory bowel disease ( 28067908) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Serum alkaline phosphatase levels ( 33547301 33339817) Type 1 diabetes ( 34012112 34127860)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) End-stage coagulation ( 23381943) Major depressive disorder ( 23377640) Mercury levels ( 26025379) Parent of origin effect on receptive language ability (paternal) ( 32635940) Photic sneeze reflex ( 27182965) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309) Response to tocilizumab in rheumatoid arthritis ( 22491018) Schizophrenia ( 33169155)
Interacting Genes		8 interacting genes: ENOX1 GSK3A GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B	14 interacting genes: AKAP11 EEF1G EIF6 ENOX2 GORASP2 LNX1 NAA16 NIF3L1 SDCBP SMIM2 SULT1E1 TRIM43 ZBTB16 ZMYND19
Entrez ID		11215	55068
HPRD ID		05261	07644
Ensembl ID		ENSG00000023516	ENSG00000120658
Uniprot IDs		Q9UKA4	A0A024RDT8 A0A024RDX6 Q8TC92
PDB IDs
Enriched GO Terms of Interacting Partners?
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