RASSF1 and STK4

Number of citations of the paper that reports this interaction (PubMedID 15109305)
144

Data Source:
HPRD (in vivo)

		RASSF1	STK4
Description		Ras association domain family member 1	serine/threonine kinase 4
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Microtubule Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity
	Biological Process	Cell Cycle Signal Transduction Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Microtubule Cytoskeleton Organization	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Protein Tetramerization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bipolar disorder ( 33263727 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		73 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BANF1 BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LARS2 LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PFDN5 PRKDC RAF1 RASSF5 RELA RHOA RHOU SMARCA4 STK11 STK4 SUV39H1 SUV39H2 TEAD2 TERT TMEM115 TMEM158 TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA	29 interacting genes: AKT1 APOBEC3C CASP3 CNKSR1 CSN1S1 DAPK2 DAXX DDIT4L EMILIN3 EPPK1 H2BC21 IL2RG KEAP1 LATS1 MAFB MAP1LC3B MARK2 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 THAP12 TP53
Entrez ID		11186	6789
HPRD ID		05470	05395
Ensembl ID		ENSG00000068028	ENSG00000101109
Uniprot IDs		Q9NS23	Q13043
PDB IDs		2KZU	2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?