DNAJB4 and RUVBL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DNAJB4	RUVBL2
Description		DnaJ heat shock protein family (Hsp40) member B4	RuvB like AAA ATPase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Dynein Axonemal Particle Ribonucleoprotein Complex
	Molecular Function	ATPase Activator Activity Protein Binding Unfolded Protein Binding Chaperone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Protein Binding ATP Binding Beta-catenin Binding ATP Hydrolysis Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity 5'-3' DNA Helicase Activity ADP Binding Unfolded Protein Binding ATPase Binding Promoter-enhancer Loop Anchoring Activity
	Biological Process	Response To Unfolded Protein Response To Heat Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Folding Histone Acetylation DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways			Telomere Extension By Telomerase HATs acetylate histones
Drugs			Quercetin
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 30224653) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference ( 25673412)	Blood protein levels ( 28240269)
Interacting Genes		10 interacting genes: HSPA6 MDM2 OPRM1 PABPN1 POLR1D RUVBL2 SDIM1 SMAD3 TBL1X TBPL2	33 interacting genes: AGR2 APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 MYC NDRG1 OGT RUVBL1 STOM TAF9 TBP TERT TXNIP YWHAQ YY1
Entrez ID		11080	10856
HPRD ID		07486	16070
Ensembl ID		ENSG00000162616	ENSG00000183207
Uniprot IDs		B4DNN2 Q9UDY4	B3KNL2 Q9Y230
PDB IDs			2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO
Enriched GO Terms of Interacting Partners?
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