TOPBP1 and RHNO1

Number of citations of the paper that reports this interaction (PubMedID 25602520)
20

Data Source:
BioGRID (affinity chromatography technology, pull down, pull down)

		TOPBP1	RHNO1
Description		DNA topoisomerase II binding protein 1	RAD9-HUS1-RAD1 interacting nuclear orphan 1
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Chromosome
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	Protein Binding
	Biological Process	DNA Metabolic Process DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Signaling	DNA Damage Checkpoint Signaling Recombinational Repair Cell Cycle Cellular Response To UV Positive Regulation Of G0 To G1 Transition Cellular Response To Ionizing Radiation
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		34 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 NPHP3 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17	12 interacting genes: BANP CYSRT1 GOLGA2 HUS1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LZTS2 RAD1 RAD9A TFIP11 TOPBP1
Entrez ID		11073	83695
HPRD ID		09678	17487
Ensembl ID		ENSG00000163781	ENSG00000171792
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	Q9BSD3
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM	6J8Y
Enriched GO Terms of Interacting Partners?
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