TOPBP1 and UBR5

  • Number of citations of the paper that reports this interaction (PubMedID 11714696)
  • 44
  • Data Source:
  • BioGRID (enzymatic study)
  • HPRD (two hybrid, in vivo, in vitro)

TOPBP1

UBR5

Description DNA topoisomerase II binding protein 1 ubiquitin protein ligase E3 component n-recognin 5
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chromosomal aberration frequency (total) ( 31586183)
  • Lymphocyte percentage of white cells ( 32888494)
  • Mean corpuscular hemoglobin ( 32888494)
  • Mean corpuscular volume ( 32888494)
  • Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209)
  • Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes 34 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 NPHP3 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17 32 interacting genes: BARD1 CIB1 CIP2A CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207
Entrez ID 11073 51366
HPRD ID 09678 06436
Ensembl ID ENSG00000163781 ENSG00000104517
Uniprot IDs A0AV47 A7E2X7 Q05BV8 Q92547 O95071
PDB IDs 1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM 1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?
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