WWP1 and KLF2

Number of citations of the paper that reports this interaction (PubMedID 11375995)
23

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		WWP1	KLF2
Description		WW domain containing E3 ubiquitin protein ligase 1	Kruppel like factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-6 Production Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression, Epigenetic Vasodilation Erythrocyte Maturation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Cycloheximide Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Cellular Stress Response To Acid Chemical Cellular Response To Peptide Negative Regulation Of Sprouting Angiogenesis
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Asthma ( 32296059) Coronary artery disease ( 33020668) Depression in smokers ( 30219690) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Systemic lupus erythematosus ( 33493351) White blood cell count ( 32888494)
Interacting Genes		58 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 DVL2 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	7 interacting genes: EP300 GATA5 GATA6 GSK3B KAT2B PSME3 WWP1
Entrez ID		11059	10365
HPRD ID		03811	03602
Ensembl ID		ENSG00000123124	ENSG00000127528
Uniprot IDs		Q9H0M0	Q9Y5W3
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y
Enriched GO Terms of Interacting Partners?
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