SDCCAG8 and RGS7

		SDCCAG8	RGS7
Description		SHH signaling and ciliogenesis regulator SDCCAG8	regulator of G protein signaling 7
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Cell-cell Junction Centriolar Satellite Ciliary Basal Body Photoreceptor Cell Cilium	Cytosol Plasma Membrane
	Molecular Function	Protein Binding	GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Neuron Migration Centrosome Cycle Establishment Of Cell Polarity Cell Projection Organization Microtubule Organizing Center Organization Tube Formation Regulation Of Cilium Assembly	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 29124443) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 28135244 27841878 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Mean platelet volume ( 32888494) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Obesity (early onset extreme) ( 20421936) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656 30285260 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Toenail selenium levels ( 25343990) Walking pace ( 33128006)	Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Ischemic stroke (cardioembolic) ( 29531354) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)
Interacting Genes		5 interacting genes: AKT3 CEP170 FBXO7 RGS7 TNS2	17 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SDCCAG8 SNAPIN YWHAB YWHAQ
Entrez ID		10806	6000
HPRD ID		10215	03948
Ensembl ID		ENSG00000054282	ENSG00000182901
Uniprot IDs		Q86SQ7	B7Z223 B7Z257 P49802
PDB IDs			2A72 2D9J
Enriched GO Terms of Interacting Partners?
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