RAD51AP1 and CACNA1C

		RAD51AP1	CACNA1C
Description		RAD51 associated protein 1	calcium voltage-gated channel subunit alpha1 C
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Postsynaptic Density Integral Component Of Membrane Z Disc Dendrite Perikaryon Postsynaptic Density Membrane L-type Voltage-gated Calcium Channel Complex
	Molecular Function	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Cellular Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Immune System Development Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Embryonic Forelimb Morphogenesis Calcium-mediated Signaling Using Extracellular Calcium Source Camera-type Eye Development Positive Regulation Of Adenylate Cyclase Activity Calcium Ion Transport Into Cytosol Cardiac Conduction Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Ibutilide Diltiazem Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine Trimebutine Barnidipine Aranidipine Benidipine Cilnidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Isavuconazole Propiverine Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)	Acoustic startle blink response ( 25387708) Adult body size ( 32376654) Adventurousness ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic root size ( 28394258) Atypical femoral fracture in phosphonate treatment ( 31006051) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365 33263727 31043756 28072414 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Broad depression or bipolar disorder ( 30626913) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Perceived intensity of aspartame ( 31005972) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Response to olanzapine in schizophrenia ( 29503163) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Schizophrenia or bipolar disorder ( 24280982) Sensorimotor dexterity ( 31596458) Short-term memory (digit-span task) ( 30741946) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Interacting Genes		9 interacting genes: APP CACNA1C DMC1 LRRK2 MAP3K1 NEDD4 PALB2 RAD51 SIAH1	28 interacting genes: ACTN2 ANKRD35 BSG C18orf32 CABP1 CACNB3 CD9 COPS5 DNAJA3 EFEMP1 FHL2 GNB1 HDAC4 IFT88 NUP133 PCBD1 PICK1 PPM1A PRKACA RAD51AP1 RIC3 RIMS1 RYR2 SRI SRRT TNIP2 VCP XRCC5
Entrez ID		10635	775
HPRD ID		04350	00246
Ensembl ID		ENSG00000111247	ENSG00000151067
Uniprot IDs		Q96B01	A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q59GU3 Q5V9X9
PDB IDs			1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ 5V2P 5V2Q 6C0A 6DAD 6DAE 6DAF 6U39 6U3A 6U3B 6U3D
Enriched GO Terms of Interacting Partners?
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