CACNA1C and ACTN2

  • Number of citations of the paper that reports this interaction (PubMedID 21653829)
  • 98
  • Data Source:
  • BioGRID (two hybrid)

CACNA1C

ACTN2

Description calcium voltage-gated channel subunit alpha1 C actinin alpha 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acoustic startle blink response ( 25387708)
  • Adult body size ( 32376654)
  • Adventurousness ( 30643258)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Aortic root size ( 28394258)
  • Atypical femoral fracture in phosphonate treatment ( 31006051)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
  • Bipolar disorder ( 18711365 33263727 31043756 28072414 20351715)
  • Bipolar disorder or major depressive disorder ( 20351715)
  • Bipolar I disorder ( 31043756)
  • Broad depression or bipolar disorder ( 30626913)
  • Broad depression or schizophrenia ( 30626913)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Diastolic blood pressure ( 30224653)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244)
  • Fractional exhaled nitric oxide (childhood) ( 24315451)
  • General risk tolerance (MTAG) ( 30643258)
  • Heel bone mineral density ( 30598549 28869591)
  • Hematocrit ( 32888494 27863252)
  • Hemoglobin ( 32888494)
  • Hemoglobin concentration ( 27863252)
  • Lumbar spine bone mineral density (integral) ( 27476799)
  • Lumbar spine bone mineral density (trabecular) ( 27476799)
  • Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Perceived intensity of aspartame ( 31005972)
  • Platelet count ( 32888494)
  • Platelet distribution width ( 32888494)
  • Plateletcrit ( 32888494)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603)
  • Psychosis proneness (hypomanic personality scale) ( 28525603)
  • Red blood cell count ( 29403010 32888494 27863252)
  • Red blood cell traits ( 23222517)
  • Response to olanzapine in schizophrenia ( 29503163)
  • Resting heart rate ( 29769521 27798624)
  • Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872)
  • Schizophrenia or bipolar disorder ( 24280982)
  • Sensorimotor dexterity ( 31596458)
  • Short-term memory (digit-span task) ( 30741946)
  • Sleep quality ( 23728906)
  • Warfarin maintenance dose ( 18535201)
Interacting Genes 28 interacting genes: ACTN2 ANKRD35 BSG C18orf32 CABP1 CACNB3 CD9 COPS5 DNAJA3 EFEMP1 FHL2 GNB1 HDAC4 IFT88 NUP133 PCBD1 PICK1 PPM1A PRKACA RAD51AP1 RIC3 RIMS1 RYR2 SRI SRRT TNIP2 VCP XRCC5 112 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKAP8L AKTIP ANG ANGPTL7 ARX ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CACNA1C CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 FXR1 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 ODF3B PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SHANK3 SMARCA2 SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TSC1 TSC2 TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2
Entrez ID 775 88
HPRD ID 00246 00019
Ensembl ID ENSG00000151067 ENSG00000077522
Uniprot IDs A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q59GU3 Q5V9X9 P35609 Q59FD9
PDB IDs 1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ 5V2P 5V2Q 6C0A 6DAD 6DAE 6DAF 6U39 6U3A 6U3B 6U3D 1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT 6TS3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?