DRAP1 and ARHGEF10L

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		DRAP1	ARHGEF10L
Description		DR1 associated protein 1	Rho guanine nucleotide exchange factor 10 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Cytosol
	Molecular Function	Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Actin Cytoskeleton Organization SREBP Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly
Pathways		Signaling by NODAL Signaling by Activin	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)	Basal cell carcinoma ( 18849993) Initial pursuit acceleration in psychotic disorders ( 29064472) Insomnia ( 27992416) Major depressive disorder x sex interaction ( 34099189) Obesity-related traits ( 23251661) Response to hepatitis C treatment ( 22095909)
Interacting Genes		31 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX1 LNX2 MCRS1 MORF4L1 NCK2 NFYB PICK1 PIK3R3 PLEKHF2 POLE3 RPL9 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	4 interacting genes: ANXA9 DRAP1 NR4A1 SCN2A
Entrez ID		10589	55160
HPRD ID		03796	07679
Ensembl ID		ENSG00000175550	ENSG00000074964
Uniprot IDs		Q14919	B4DTL3 Q5VXI4 Q9HCE6
PDB IDs		1JFI
Enriched GO Terms of Interacting Partners?
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