SPTLC1 and SPTLC2

Number of citations of the paper that reports this interaction (PubMedID 10722674)
32

Data Source:
HPRD (in vivo, in vitro)

		SPTLC1	SPTLC2
Description		serine palmitoyltransferase long chain base subunit 1	serine palmitoyltransferase long chain base subunit 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex SPOTS Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding Pyridoxal Phosphate Binding	Serine C-palmitoyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Lipophagy Regulation Of Fat Cell Apoptotic Process	Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Adipose Tissue Development Positive Regulation Of Lipophagy
Pathways		Sphingolipid de novo biosynthesis	Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate Serine	Pyridoxal phosphate Serine
Diseases
GWAS		Bipolar disorder and schizophrenia ( 22688191) Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction) ( 25140149) Serum immune biomarker levels ( 32066700)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Red cell distribution width ( 32888494)
Interacting Genes		5 interacting genes: ABCA1 GABBR2 GTF2IRD1 SPTLC2 TRIM38	2 interacting genes: NOTCH3 SPTLC1
Entrez ID		10558	9517
HPRD ID		05754	05755
Ensembl ID		ENSG00000090054	ENSG00000100596
Uniprot IDs		A0A024R277 O15269 Q6NUL7	A0A024R6H1 O15270
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q	6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q
Enriched GO Terms of Interacting Partners?
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