SPTLC1

Description		serine palmitoyltransferase long chain base subunit 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex SPOTS Complex
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding Pyridoxal Phosphate Binding
	Biological Process	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Lipophagy Regulation Of Fat Cell Apoptotic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Bipolar disorder and schizophrenia ( 22688191) Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction) ( 25140149) Serum immune biomarker levels ( 32066700)
Interacting Genes		5 interacting genes: ABCA1 GABBR2 GTF2IRD1 SPTLC2 TRIM38
Entrez ID		10558
HPRD ID		05754
Ensembl ID		ENSG00000090054
Uniprot IDs		A0A024R277 O15269 Q6NUL7
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q
Enriched GO Terms of Interacting Partners?
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