DEAF1 and PELI2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DEAF1	PELI2
Description		DEAF1 transcription factor	pellino E3 ubiquitin protein ligase family member 2
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm	Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Germ Cell Development Anatomical Structure Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade
Pathways			Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS			Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		23 interacting genes: AIMP2 ASCC2 CDC37 CDKN1A CDKN2A CEP76 FHL1 FHL2 FXR1 FXR2 GOLGA3 GSK3A GSK3B HRAS INTS1 LMO4 PELI2 PIN1 PPP1CA PPP1CC RAD23B RIDA TK1	35 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TIMM9 TMEM79 TP53 TP63 TRIM32 UBQLN4
Entrez ID		10522	57161
HPRD ID		04027	17835
Ensembl ID		ENSG00000177030	ENSG00000139946
Uniprot IDs		O75398	Q9H716 Q9HAT8
PDB IDs		2JW6 4A24 5UWW	3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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