TOMM40 and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 25591737)
10

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TOMM40	HSD17B10
Description		translocase of outer mitochondrial membrane 40	hydroxysteroid 17-beta dehydrogenase 10
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Integral Component Of Mitochondrial Outer Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Pore Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Porin Activity	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Estradiol 17-beta-dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
	Biological Process	Protein Targeting To Mitochondrion Ion Transport Protein Import Into Mitochondrial Matrix	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs			NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases
GWAS		Age-related macular degeneration ( 22694956 23326517) Alzheimer's disease ( 22832961 24770881 30636644 18823527 19734902 29107063 24755620 19125160 20061627) Alzheimer's disease (age of onset) ( 29107063 22005931) Alzheimer's disease (late onset) ( 20885792 23565137 26339675) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 33730874) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 26833246) Body fat percentage and coronary artery disease (pairwise) ( 33619380) Body fat percentage and HDL-C (pairwise) ( 33619380) Body fat percentage and LDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and LDL-C (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain imaging ( 20100581) C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 30319691 28641921 29274321 20932310) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30319691 28641921) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 19060911) Cingulate cortical amyloid beta load ( 26421299) Cognitive decline ( 22054870 23207651) Cognitive decline (age-related) ( 28078323 24468470) Cognitive function ( 25644384) Cognitive impairment test score ( 30319691) Coronary artery disease ( 29212778) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) HDL cholesterol ( 21909109 19060911) Hippocampal atrophy rate ( 31760383) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lamb consumption ( 32066663) LDL cholesterol ( 26160806 19060911) LDL cholesterol levels ( 26763881) Lipid traits ( 24386095) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21418511 33657282) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 22399527) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Quantitative traits ( 19197348) Refractive error ( 32231278) Sense of smell ( 26632684) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum type 1 collagen metabolite levels ( 33134509) Triglycerides ( 19060911) Type 2 diabetes ( 27189021 30297969) Verbal declarative memory ( 25648963) Verbal memory performance (immediate recall change) ( 28800603) Verbal memory performance (residualized delayed recall level) ( 28800603) Waist circumference ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-hip ratio and coronary artery disease (pairwise) ( 33619380) Waist-hip ratio and HDL-C (pairwise) ( 33619380) Waist-hip ratio and LDL-C (pairwise) ( 33619380) Waist-hip ratio and triglycerides (pairwise) ( 33619380) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		7 interacting genes: HSD17B10 HSP90AA1 HSPA4 MTX1 PRKN SAMM50 TOMM7	32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 KDM6A MDH1 OGDH PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		10452	3028
HPRD ID		16274	02223
Ensembl ID		ENSG00000130204	ENSG00000072506
Uniprot IDs		O96008	A0A0S2Z410 Q99714
PDB IDs		7CK6	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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