HSD17B10 and TRAF3IP2

Number of citations of the paper that reports this interaction (PubMedID 22496890)
6

Data Source:
BioGRID (two hybrid)

		HSD17B10	TRAF3IP2
Description		hydroxysteroid 17-beta dehydrogenase 10	TRAF3 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid	Cellular_component Cytoplasmic Vesicle
	Molecular Function	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Estradiol 17-beta-dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Signaling Receptor Binding Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Establishment Of T Cell Polarity B Cell Homeostasis B Cell Apoptotic Process Kidney Development Positive Regulation Of Defense Response To Virus By Host Leukocyte Activation Involved In Inflammatory Response Transitional Two Stage B Cell Differentiation B Cell Affinity Maturation Eosinophil Mediated Immunity Protein Import Into Nucleus Inflammatory Response Humoral Immune Response Heart Development Response To Xenobiotic Stimulus Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway T Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-17A-mediated Signaling Pathway Type 2 Immune Response Neutrophil Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skin Development MRNA Stabilization Lymph Node Development Spleen Development Mucus Secretion Protein K63-linked Ubiquitination T-helper 17 Type Immune Response Interleukin-17-mediated Signaling Pathway Protein Localization To P-body Eosinophil Homeostasis
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062)	Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Psoriasis ( 25903422 20953188 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 KDM6A MDH1 OGDH PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	23 interacting genes: CD40 CHUK FHL3 GOLGA2 HSD17B10 IKBKB IKBKG MAP3K7 MDFI MRPL28 RIMBP3 STK16 TBK1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 TRIP6 UBC UBE2V1
Entrez ID		3028	10758
HPRD ID		02223	06129
Ensembl ID		ENSG00000072506	ENSG00000056972
Uniprot IDs		A0A0S2Z410 Q99714	O43734
PDB IDs		1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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