FAM3C and HHLA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FAM3C	HHLA2
Description		FAM3 metabolism regulating signaling molecule C	HERV-H LTR-associating 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Platelet Dense Granule Lumen Extracellular Exosome	Cellular_component External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Protein Binding	Molecular_function Signaling Receptor Binding Protein Binding
	Biological Process	Signal Transduction Biological_process Negative Regulation Of Gluconeogenesis	Regulation Of Cytokine Production Positive Regulation Of Cytokine Production T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Receptor Signaling Pathway
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Biomedical quantitative traits ( 19396169) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Calcaneus stiffness index ( 30779856) Forearm bone mineral density ( 26367794) Hand grip strength ( 27325353) Heel bone mineral density ( 30598549 28869591) Lung adenocarcinoma ( 28604730) Pediatric bone mineral content (radius) ( 26041818) Phenylephrine infusion rate during anesthesia ( 31455332) Total body bone mineral density ( 30172743) Ulna and radius bone mineral density ( 30172743)	Regular attendance at a religious group ( 29970889)
Interacting Genes		48 interacting genes: AHNAK2 BIK BNIP2 CLEC17A CLEC2D CLEC4E CREB3 CREB3L1 CXADR CYB5R3 ELOVL4 ERGIC3 EVI2B FAM209A FCGR1A FCGRT FFAR2 FKBP7 GGT6 GJB5 GPR42 GPX8 HHLA2 KCNA2 KIR2DL3 LMNA LRRC25 MFF PDZK1IP1 RELL2 RMDN3 RNASEH1 SAR1A SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35C2 SPINT1 SSMEM1 STX1A TEX29 TMEM248 TMEM45B TMEM71 TMEM80 TMPRSS2 TMX2	14 interacting genes: AQP9 BRICD5 BTNL8 C3orf52 ERMP1 FAM3C NIPAL4 NRM PGA4 RPRM SMCO4 TMEM140 TNMD UNC93B1
Entrez ID		10447	11148
HPRD ID		12270	05082
Ensembl ID		ENSG00000196937	ENSG00000114455
Uniprot IDs		Q92520	C9J7D0 Q9UM44
PDB IDs		5LC2
Enriched GO Terms of Interacting Partners?
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