TRAIP and POLK

Number of citations of the paper that reports this interaction (PubMedID 24553286)
15

Data Source:
BioGRID (two hybrid)

		TRAIP	POLK
Description		TRAF interacting protein	DNA polymerase kappa
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Perinuclear Region Of Cytoplasm Site Of DNA Damage	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Damaged DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Replication Fork Processing Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Protein-DNA Covalent Cross-linking Repair	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Cellular Response To UV Error-prone Translesion Synthesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Fasting insulin ( 34059833) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mental health study participation (provided email address) ( 31263887) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Walking pace ( 33128006)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Iron status biomarkers (transferrin saturation) ( 28334935)
Interacting Genes		28 interacting genes: ALOX15B APP CEP19 CYLD FLII LXN MAGEF1 MAPRE2 MAPRE3 POLK POLR1C RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 USP2	5 interacting genes: PCNA RAD18 REV1 TRAIP WRN
Entrez ID		10293	51426
HPRD ID		05811	09291
Ensembl ID		ENSG00000183763	ENSG00000122008
Uniprot IDs		Q9BWF2	A0A024RAP4 Q9UBT6
PDB IDs		4ZTD	1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST
Enriched GO Terms of Interacting Partners?
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