ABCC4 and PDZK1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ABCC4	PDZK1
Description		ATP binding cassette subfamily C member 4	PDZ domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Platelet Dense Granule Membrane External Side Of Apical Plasma Membrane	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Guanine Nucleotide Transmembrane Transporter Activity Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Prostaglandin Transmembrane Transporter Activity Urate Transmembrane Transporter Activity Purine Nucleotide Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity Efflux Transmembrane Transporter Activity P-type Ion Transporter Activity 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding
	Biological Process	Platelet Degranulation Response To Xenobiotic Stimulus Response To Organonitrogen Compound Response To Organic Cyclic Compound Inorganic Anion Transport Bile Acid And Bile Salt Transport Prostaglandin Transport Urate Transport Prostaglandin Secretion Glutathione Transmembrane Transport Bile Acid Signaling Pathway Xenobiotic Transport Positive Regulation Of Smooth Muscle Cell Proliferation Transmembrane Transport Cilium Assembly CAMP Transport Leukotriene Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Guanine Nucleotide Transmembrane Transport	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Platelet degranulation ABC-family proteins mediated transport
Drugs		ATP
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Blood metabolite levels ( 24816252) Breast cancer ( 17903305) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 20834067) Parent of origin effect on language impairment (paternal) ( 24571439) Platelet count ( 22139419 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Postherpetic neuralgia ( 33685280) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653) Serum metabolite levels ( 33031748)	Contrast sensitivity ( 24152035) Gout ( 33832965 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Interacting Genes		6 interacting genes: ERBIN MPP1 PDZK1 SLC9A3R1 SLC9A3R2 SNTA1	31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		10257	5174
HPRD ID		05583	04829
Ensembl ID		ENSG00000125257	ENSG00000174827
Uniprot IDs		A8K2Q2 O15439	Q5T2W1
PDB IDs			2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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