PDZK1 and SLC22A11

Number of citations of the paper that reports this interaction (PubMedID 16236806)
27

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PDZK1	SLC22A11
Description		PDZ domain containing 1	solute carrier family 22 member 11
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding	Inorganic Anion Exchanger Activity Protein Binding Organic Anion Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Inorganic Anion Transport Organic Anion Transport Urate Metabolic Process Transmembrane Transport
Pathways			Organic anion transport
Drugs			Cefotaxime Probenecid Ceftriaxone Lesinurad
Diseases
GWAS		Contrast sensitivity ( 24152035) Gout ( 33832965 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Body mass index ( 32363570) Gout ( 33832965 32238385) Gout vs asymptomatic hyperuricemia ( 33832965) Obesity-related traits ( 23251661) Renal underexcretion gout ( 32238385) Serum uric acid levels ( 30993211 26902266) Systemic lupus erythematosus ( 28714469) Urate levels ( 20884846 31578528 23263486) Urate levels in lean individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	3 interacting genes: CAV3 PDZK1 SLC9A3R1
Entrez ID		5174	55867
HPRD ID		04829	06161
Ensembl ID		ENSG00000174827	ENSG00000168065
Uniprot IDs		Q5T2W1	Q9NSA0
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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