GPHN and ARHGEF9

Number of citations of the paper that reports this interaction (PubMedID 10607391)
95

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		GPHN	ARHGEF9
Description		gephyrin	Cdc42 guanine nucleotide exchange factor 9
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Dendrite Postsynaptic Membrane Synaptic Membrane Anchored Component Of Synaptic Membrane Postsynaptic Specialization Postsynaptic Specialization Membrane	Cytosol Postsynaptic Density
	Molecular Function	Protein Binding ATP Binding Nitrate Reductase Activity Identical Protein Binding Molybdopterin Cofactor Binding Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Glycine Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Postsynaptic Neurotransmitter Receptor Diffusion Trapping	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Molybdenum cofactor biosynthesis	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOQ GTPase cycle GABA receptor activation GABA receptor activation
Drugs		Formic acid Imidazole Propanoic acid
Diseases
GWAS		Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)	Male-pattern baldness ( 28196072)
Interacting Genes		15 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MITD1 MTOR PFN1 PIN1 PSMA1 SPATS1 TUBA4A	11 interacting genes: BCL6 CDC42 FAM90A1 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TBC1D22B TFIP11 TSGA10IP
Entrez ID		10243	23229
HPRD ID		04893	02337
Ensembl ID		ENSG00000171723	ENSG00000131089
Uniprot IDs		Q9NQX3	B1AMR3 O43307
PDB IDs		1JLJ	2YSQ
Enriched GO Terms of Interacting Partners?
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