PATJ and GLS2

Number of citations of the paper that reports this interaction (PubMedID 16637659)
29

Data Source:
HPRD (in vitro)

		PATJ	GLS2
Description		PATJ crumbs cell polarity complex component	glutaminase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Glutaminase Activity Protein Binding
	Biological Process	Microtubule Organizing Center Organization Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Regulation Of Microtubule Cytoskeleton Organization Tight Junction Assembly	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process
Pathways			Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs			Glutamic acid
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 33730874) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	17 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 OS9 PAG1 PATJ PDE2A RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1
Entrez ID		10207	27165
HPRD ID		04434	05901
Ensembl ID		ENSG00000132849	ENSG00000135423
Uniprot IDs			A0A087X004 Q9UI32
PDB IDs			4BQM 5U0K
Enriched GO Terms of Interacting Partners?
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