OPTN and HACE1

  • Number of citations of the paper that reports this interaction (PubMedID 25026213)
  • 90
  • Data Source:
  • BioGRID (enzymatic study, affinity chromatography technology)

OPTN

HACE1

Description optineurin HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Age at first sexual intercourse ( 34211149)
  • Age at voice drop ( 27182965)
  • Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
  • Feeling guilty ( 29500382)
  • Height ( 18391951)
  • Hip circumference adjusted for BMI ( 34021172)
  • Intraocular pressure ( 29617998)
  • Major depressive disorder ( 27479909)
  • Menarche (age at onset) ( 19448622 27182965)
  • Multiple sclerosis ( 23412934)
  • Neuroblastoma ( 22941191)
  • Obsessive-compulsive disorder ( 22889921)
  • Resistant hypertension ( 31545351)
  • Schizophrenia ( 28991256)
  • Sporadic neuroblastoma ( 28545128)
  • Thyroid stimulating hormone levels ( 17903292)
  • Type 2 diabetes ( 31049640)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in inactive individuals ( 28448500)
  • Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes 71 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CDK4 CLTC CMYA5 DAZAP2 DYSF DZIP1 FAM189A2 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAILR MAP1LC3A MAP1LC3B MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNX6 TBC1D15 TBC1D17 TNIP1 UBB UQCRQ USP2 VCP WASHC3 WIPI2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711 9 interacting genes: MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID 10133 57531
HPRD ID 03891 17086
Ensembl ID ENSG00000123240 ENSG00000085382
Uniprot IDs Q96CV9 Q8IYU2
PDB IDs 2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?