TOM1L1 and PDPN

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TOM1L1	PDPN
Description		target of myb1 like 1 membrane trafficking protein	podoplanin
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Membrane Extracellular Exosome	Ruffle Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Cell Junction Filopodium Lamellipodium Membrane Cytoplasmic Vesicle Filopodium Membrane Microvillus Membrane Ruffle Membrane Cell Projection Membrane Raft Leading Edge Of Lamellipodium Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Phosphatidylinositol Binding Ubiquitin Binding	Signaling Receptor Binding Water Transmembrane Transporter Activity Protein Binding Folic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Water Channel Activity Chemokine Binding Chaperone Binding
	Biological Process	Signal Transduction Protein Transport Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Cell Morphogenesis Lymphangiogenesis Water Transport Amino Acid Transport Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Folic Acid Transport Platelet Activation Lung Development Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Process Wound Healing, Spreading Of Cells Lymph Node Development Positive Regulation Of Cellular Component Movement Response To Hyperoxia Lymphatic Endothelial Cell Fate Commitment Actin-mediated Cell Contraction Positive Regulation Of Extracellular Matrix Disassembly Cell-cell Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Regulation Of Myofibroblast Contraction Regulation Of Lamellipodium Morphogenesis
Pathways			GPVI-mediated activation cascade
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Systolic blood pressure ( 34074324) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		29 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 DNAJB13 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP	7 interacting genes: CELA2B LHX1 PRDM2 PRMT1 TMEM14B TOM1L1 ZBTB48
Entrez ID		10040	10630
HPRD ID		05266	16398
Ensembl ID		ENSG00000141198	ENSG00000162493
Uniprot IDs		O75674 Q8NI65	Q86YL7
PDB IDs		3RRU	3WSR 4YO0 5XCV 7C94
Enriched GO Terms of Interacting Partners?
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