ALDOA and SUMO4 |
aldolase, fructose-bisphosphate A |
small ubiquitin like modifier 4 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
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- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
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ALDOA and BCAT2 |
aldolase, fructose-bisphosphate A |
branched chain amino acid transaminase 2 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Branched-chain amino acid catabolism
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
- Pyridoxal Phosphate
- Glutamic Acid
- L-Leucine
- L-Isoleucine
- Pyridoxamine-5'-Phosphate
- N-[O-Phosphono-Pyridoxyl]-Isoleucine
- Alpha-ketoisovalerate
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ALDOA and SRPK2 |
aldolase, fructose-bisphosphate A |
SRSF protein kinase 2 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
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- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
- Adenine
- Purvalanol
- Phosphoaminophosphonic Acid-Adenylate Ester
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ALDOA and FANCA |
aldolase, fructose-bisphosphate A |
FA complementation group A |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and XRN1 |
aldolase, fructose-bisphosphate A |
5'-3' exoribonuclease 1 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- mRNA decay by 5' to 3' exoribonuclease
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and TRIM63 |
aldolase, fructose-bisphosphate A |
tripartite motif containing 63 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Antigen processing: Ubiquitination & Proteasome degradation
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and PLD2 |
aldolase, fructose-bisphosphate A |
phospholipase D2 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Synthesis of PG
- Synthesis of PA
- Role of phospholipids in phagocytosis
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and DYNLL1 |
aldolase, fructose-bisphosphate A |
dynein light chain LC8-type 1 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Activation of BIM and translocation to mitochondria
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Macroautophagy
- MHC class II antigen presentation
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- Intraflagellar transport
- RHO GTPases Activate Formins
- Neutrophil degranulation
- COPI-mediated anterograde transport
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- AURKA Activation by TPX2
- HCMV Early Events
- Aggrephagy
- Aggrephagy
- EML4 and NUDC in mitotic spindle formation
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- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and ALDOB |
aldolase, fructose-bisphosphate A |
aldolase, fructose-bisphosphate B |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Hereditary fructose intolerance
- Glycolysis
- Gluconeogenesis
- Fructose catabolism
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
- 1,6-Fructose Diphosphate (Linear Form)
- 3-Phosphoglycerol
- Dihydroxyacetone phosphate
|
|
- Hereditary fructose intolerance; Fructosemia
|
ALDOA and CACNA1A |
aldolase, fructose-bisphosphate A |
calcium voltage-gated channel subunit alpha1 A |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Presynaptic depolarization and calcium channel opening
- Regulation of insulin secretion
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- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
- Pregabalin
- Spironolactone
- Verapamil
- Loperamide
- Bepridil
|
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- Episodic ataxias
- Familial or sporadic hemiplegic migraine
- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
|
ALDOA and HSPB2 |
aldolase, fructose-bisphosphate A |
heat shock protein family B (small) member 2 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
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- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and TUBB |
aldolase, fructose-bisphosphate A |
tubulin beta class I |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- Neutrophil degranulation
- AURKA Activation by TPX2
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
- Vinorelbine
- Vincristine
- Vinblastine
- Podofilox
- Colchicine
- Epothilone D
- Patupilone
- CYT997
- CA4P
- ZEN-012
- Copper
- Depatuxizumab mafodotin
- Milataxel
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ALDOA and TGM2 |
aldolase, fructose-bisphosphate A |
transglutaminase 2 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and TERF1 |
aldolase, fructose-bisphosphate A |
telomeric repeat binding factor 1 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Telomere Extension By Telomerase
- DNA Damage/Telomere Stress Induced Senescence
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and IFNA4 |
aldolase, fructose-bisphosphate A |
interferon alpha 4 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Interferon alpha/beta signaling
- Regulation of IFNA signaling
- Regulation of IFNA signaling
- TRAF6 mediated IRF7 activation
- Factors involved in megakaryocyte development and platelet production
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and EGFR |
aldolase, fructose-bisphosphate A |
epidermal growth factor receptor |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Signaling by ERBB2
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Signaling by ERBB4
- SHC1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- PLCG1 events in ERBB2 signaling
- PIP3 activates AKT signaling
- Signaling by EGFR
- GRB2 events in EGFR signaling
- GAB1 signalosome
- SHC1 events in EGFR signaling
- EGFR downregulation
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- EGFR interacts with phospholipase C-gamma
- EGFR Transactivation by Gastrin
- Constitutive Signaling by Aberrant PI3K in Cancer
- Signal transduction by L1
- Constitutive Signaling by EGFRvIII
- Inhibition of Signaling by Overexpressed EGFR
- RAF/MAP kinase cascade
- ERBB2 Regulates Cell Motility
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- ERBB2 Activates PTK6 Signaling
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- PTK6 promotes HIF1A stabilization
- Downregulation of ERBB2 signaling
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Extra-nuclear estrogen signaling
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- HCMV Early Events
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- Signaling by ERBB2 KD Mutants
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Alvocidib
- IGN311
- Matuzumab
- Vandetanib
- Rindopepimut
- Canertinib
- Pelitinib
- Varlitinib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
- Osimertinib
- Necitumumab
- Depatuxizumab mafodotin
- Icotinib
- Neratinib
- Zalutumumab
- Brigatinib
- Olmutinib
|
|
- Choriocarcinoma
- Gastric cancer
- Bladder cancer
- Oral cancer
- Glioma
- Laryngeal cancer
- Cervical cancer
- Esophageal cancer
|
ALDOA and PIAS4 |
aldolase, fructose-bisphosphate A |
protein inhibitor of activated STAT 4 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Vitamin D (calciferol) metabolism
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of DNA replication proteins
- SUMOylation of immune response proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- G2/M DNA damage checkpoint
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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ALDOA and MLH1 |
aldolase, fructose-bisphosphate A |
mutL homolog 1 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Defective Mismatch Repair Associated With MLH1
- Defective Mismatch Repair Associated With PMS2
- TP53 Regulates Transcription of DNA Repair Genes
- Meiotic recombination
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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- Colorectal cancer
- Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
- Endometrial Cancer
- Ovarian cancer
|
ALDOA and HSD17B10 |
aldolase, fructose-bisphosphate A |
hydroxysteroid 17-beta dehydrogenase 10 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- tRNA processing in the mitochondrion
- tRNA modification in the mitochondrion
- Branched-chain amino acid catabolism
- rRNA processing in the mitochondrion
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
- NADH
- 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
|
|
- 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
- Non-syndromic X-linked mental retardation
- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
|
ALDOA and GALNT6 |
aldolase, fructose-bisphosphate A |
polypeptide N-acetylgalactosaminyltransferase 6 |
- Platelet degranulation
- Neutrophil degranulation
- Glycolysis
- Gluconeogenesis
|
- O-linked glycosylation of mucins
|
- Zinc
- 1,6-Fructose Diphosphate (Linear Form)
- Dihydroxyacetone phosphate
- 1,6-DI-O-PHOSPHONO-D-MANNITOL
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
|
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