ALDOA and ALDOB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ALDOA	ALDOB
Description		aldolase, fructose-bisphosphate A	aldolase, fructose-bisphosphate B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Secretory Granule Lumen Sperm Head Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Microtubule Organizing Center Cytosol Centriolar Satellite Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Identical Protein Binding Cadherin Binding Fructose Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding ATPase Binding Fructose-1-phosphate Aldolase Activity Fructose Binding
	Biological Process	Platelet Degranulation Fructose Metabolic Process Gluconeogenesis Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Binding Of Sperm To Zona Pellucida Regulation Of Cell Shape Fructose 1,6-bisphosphate Metabolic Process Neutrophil Degranulation Muscle Cell Cellular Homeostasis Protein Homotetramerization Canonical Glycolysis	Fructose Metabolic Process Gluconeogenesis Glycolytic Process NADH Oxidation Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of ATPase Activity Canonical Glycolysis Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly
Pathways		Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis	Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism
Drugs		Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE	1,6-Fructose Diphosphate (Linear Form) 3-Phosphoglycerol Dihydroxyacetone phosphate
Diseases			Hereditary fructose intolerance; Fructosemia
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Schizophrenia ( 25056061 29483656)	Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010)
Interacting Genes		26 interacting genes: ADRB2 ALDOB ATP6V1E1 BCAT2 CACNA1A CYTH2 DYNLL1 EGFR FANCA GALNT6 GPD2 HSD17B10 HSPB2 IFNA4 MLH1 MYOC PCNA PIAS4 PLD2 SRPK2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	8 interacting genes: AGXT2 ALDOA APP ATP6V1E1 HIVEP1 HSPA8 MUC20 TXN2
Entrez ID		226	229
HPRD ID		00070	01972
Ensembl ID		ENSG00000149925	ENSG00000136872
Uniprot IDs		P04075 V9HWN7	A0A024R145 P05062
PDB IDs		1ALD 2ALD 4ALD 5KY6	1QO5 1XDL 1XDM
Enriched GO Terms of Interacting Partners?
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