KCNE2 and KCNH2

Number of citations of the paper that reports this interaction (PubMedID 11278781)
20

Data Source:
HPRD (in vivo)

		KCNE2	KCNH2
Description		potassium voltage-gated channel subfamily E regulatory subunit 2	potassium voltage-gated channel subfamily H member 2
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GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Identical Protein Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity C3HC4-type RING Finger Domain Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Aging Cellular Response To Drug Tongue Development Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Inward Rectifier Potassium Channel Activity Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane	Regulation Of Heart Rate By Hormone Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Voltage gated Potassium channels Phase 3 - rapid repolarisation
Drugs			Fluvoxamine Erythromycin Dofetilide Amsacrine Disopyramide Ibutilide Terfenadine Alfuzosin Loratadine Prazosin Imipramine Fluoxetine Chlorpromazine Sotalol Ciprofloxacin Doxazosin Cisapride Astemizole Verapamil Tamoxifen Thioridazine Quinidine Ketoconazole Procainamide Perhexiline Pimozide Miconazole Amiodarone Carvedilol Doxepin Nefazodone Terazosin Propafenone Flecainide Clarithromycin Halofantrine Bepridil Dronedarone Azimilide Sertindole Vernakalant Chlorobutanol
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Short QT syndrome
GWAS		Body mass index (smoking years interaction) ( 23192594) Cancer ( 29299148) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 24262325 30104761 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 28166213 30804560) Myocardial infarction ( 26708285 26343387) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)	Atrial fibrillation ( 30061737 29892015) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronotype ( 30696823) Diverticular disease ( 30177863) Electrocardiographic traits ( 20062061 20062063) Eyebrow thickness ( 26926045) Metabolic syndrome ( 31589552) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149)
Interacting Genes		2 interacting genes: KCNH2 KCNQ1	10 interacting genes: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		9992	3757
HPRD ID		04813	01069
Ensembl ID		ENSG00000159197	ENSG00000055118
Uniprot IDs		Q9Y6J6	A0A090N7W1 A0A090N7X5 A0A090N8Q0 Q12809 Q15BH2
PDB IDs		2M0Q	1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 2N7G 4HP9 4HQA 5VA1 5VA2 5VA3
Enriched GO Terms of Interacting Partners?
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