KCNH2 and NDUFS6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KCNH2	NDUFS6
Description		potassium voltage-gated channel subfamily H member 2	NADH:ubiquinone oxidoreductase subunit S6
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity C3HC4-type RING Finger Domain Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity
	Biological Process	Regulation Of Heart Rate By Hormone Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Kidney Development Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Metabolic Process Muscle Contraction Multicellular Organism Aging Mitochondrial Respiratory Chain Complex I Assembly Multicellular Organism Growth Reproductive System Development Mitochondrion Morphogenesis Cardiovascular System Development
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation	Respiratory electron transport Complex I biogenesis
Drugs		Fluvoxamine Erythromycin Dofetilide Amsacrine Disopyramide Ibutilide Terfenadine Alfuzosin Loratadine Prazosin Imipramine Fluoxetine Chlorpromazine Sotalol Ciprofloxacin Doxazosin Cisapride Astemizole Verapamil Tamoxifen Thioridazine Quinidine Ketoconazole Procainamide Perhexiline Pimozide Miconazole Amiodarone Carvedilol Doxepin Nefazodone Terazosin Propafenone Flecainide Clarithromycin Halofantrine Bepridil Dronedarone Azimilide Sertindole Vernakalant Chlorobutanol	NADH
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Short QT syndrome	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Atrial fibrillation ( 30061737 29892015) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronotype ( 30696823) Diverticular disease ( 30177863) Electrocardiographic traits ( 20062061 20062063) Eyebrow thickness ( 26926045) Metabolic syndrome ( 31589552) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149)	Lack of perseverance ( 30718321) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH	5 interacting genes: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2
Entrez ID		3757	4726
HPRD ID		01069	10356
Ensembl ID		ENSG00000055118	ENSG00000145494
Uniprot IDs		A0A090N7W1 A0A090N7X5 A0A090N8Q0 Q12809 Q15BH2	O75380 Q6IBC4
PDB IDs		1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 2N7G 4HP9 4HQA 5VA1 5VA2 5VA3	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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