RBX1 and UBE2L3

Number of citations of the paper that reports this interaction (PubMedID 30244836)
19

Data Source:
BioGRID (pull down)

		RBX1	UBE2L3
Description		ring-box 1	ubiquitin conjugating enzyme E2 L3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Nuclear SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein-containing Complex Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	MAPK Cascade Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Global Genome Nucleotide-excision Repair Negative Regulation Of Canonical Wnt Signaling Pathway	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Recognition of DNA damage by PCNA-containing replication complex Prolactin receptor signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Degradation of DVL Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Orc1 removal from chromatin FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Crohn's disease ( 22936669) Neuroticism ( 29255261)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Ankylosing spondylitis ( 23749187) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) HDL cholesterol ( 24097068 25961943 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hepatitis B ( 24162738) High density lipoprotein cholesterol levels ( 29403010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 29403010 20139978 27863252 28017375) Neutrophil percentage of white cells ( 27863252) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Psoriasis ( 23143594) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 23273568 26502338 21408207 28714469 19838193 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Total cholesterol levels ( 30275531) Ulcerative colitis ( 28067908)
Interacting Genes		68 interacting genes: APP CAND1 CAND2 CCND1 CDC34 CDKN1B COPS6 CRBN CSNK1E CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 DCAF1 DESI1 DTL EP300 ERBIN ERCC8 FBH1 FBXW8 FRZB GHR GLMN GPS1 GRAP2 HAX1 KCTD17 KIDINS220 MAGEC2 MAP3K20 MAP3K7 MAPK8IP2 MKNK2 MYB NTHL1 OS9 PML PMM1 PRAME RHOBTB3 RNF126 RPS6KB1 S100A12 SEPTIN3 SERTAD1 SFTPD SKP1 SMAD3 TAB1 TRIM27 TRIM74 UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2M UBE2R2 VHL VRK2	113 interacting genes: ANKIB1 AREL1 ARIH1 ARIH2 ATXN3 BRAF BRAP BRCA1 CBL CBLB CBLC CCNB1IP1 CDKN1B CUL9 DTX3 FBXO2 FOS HACE1 HECTD1 HECTD2 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC3 HERC4 HERC6 HSPA4 HUWE1 IRF2BP1 ITCH KSR1 LIG4 LTN1 MAP2K1 MAPK6 MDM2 MEX3A MEX3C MID1 MKRN3 MUL1 MYCBP2 NEDD4 NEDD4L NFKBIA NR3C1 NRAS PIAS1 PIAS2 PJA1 POLR2A PRKN PTEN RAF1 RBCK1 RBX1 RC3H1 RELA RNF103 RNF113B RNF114 RNF125 RNF14 RNF144A RNF144B RNF150 RNF168 RNF170 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF31 RNF7 RTF2 SMAD4 SMAD7 SMURF1 SMURF2 SPOP STUB1 TP53 TRAF6 TRAF7 TRIM21 TRIM23 TRIM25 TRIM28 TRIM31 TRIM39 TRIM55 TRIP12 UBA1 UBA5 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR4 UBR5 VPS11 WIPI2 WWP1 WWP2 YWHAQ
Entrez ID		9978	7332
HPRD ID		06794	04762
Ensembl ID		ENSG00000100387	ENSG00000185651
Uniprot IDs		P62877	A0A024R1A4 P68036
PDB IDs		1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52 4P5O 5N4W	1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13
Enriched GO Terms of Interacting Partners?
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