NR1I3 and CHD9

Number of citations of the paper that reports this interaction (PubMedID 16554032)
14

Data Source:
HPRD (in vitro)

		NR1I3	CHD9
Description		nuclear receptor subfamily 1 group I member 3	chromodomain helicase DNA binding protein 9
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton RNA Polymerase II Transcription Factor Complex	Nucleoplasm Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	DNA Binding DNA Helicase Activity ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Signal Transduction Multicellular Organism Development Cell Differentiation Intracellular Receptor Signaling Pathway Response To Lipid Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Lipopolysaccharide	Chromatin Organization Regulation Of Lipid Metabolic Process DNA Duplex Unwinding
Pathways			RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock
Drugs		Clotrimazole Doxylamine Meclizine Loperamide Ketoconazole Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein (5BETA)-PREGNANE-3,20-DIONE Hexestrol Triclosan
Diseases
GWAS		Blood metabolite levels ( 24816252)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Morning person ( 30696823) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		18 interacting genes: CHD9 DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC	5 interacting genes: ESR1 NR1I3 NR3C1 PPARA RXRA
Entrez ID		9970	80205
HPRD ID		04858	08570
Ensembl ID		ENSG00000143257	ENSG00000177200
Uniprot IDs		F1DAL4 Q14994	Q3L8U1
PDB IDs		1XV9 1XVP
Enriched GO Terms of Interacting Partners?
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