MVP and HP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MVP	HP
Description		major vault protein	haptoglobin
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Protein Transport Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Neutrophil Degranulation MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity	Acute Inflammatory Response Proteolysis Receptor-mediated Endocytosis Defense Response Acute-phase Response Response To Organic Substance Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Neutrophil degranulation	Scavenging of heme from plasma Neutrophil degranulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		58 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 EPHX2 ESR1 GIT2 GOLGA2 HP IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC VAC14 ZBTB32 ZMIZ2	21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		9961	3240
HPRD ID		05475	00772
Ensembl ID		ENSG00000013364	ENSG00000257017
Uniprot IDs		Q14764 X5D2M8 X5D7K9 X5DNU0	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs		1Y7X	4WJG 4X0L 5HU6
Enriched GO Terms of Interacting Partners?
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