GCSH and ING5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GCSH	ING5
Description		glycine cleavage system protein H	inhibitor of growth family member 5
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Aminomethyltransferase Activity Protein Binding	Chromatin Binding Protein Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System	DNA Replication Protein Acetylation Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Glyoxylate metabolism and glycine degradation Glycine degradation	HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs		Glycine 6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433)
Interacting Genes		4 interacting genes: ING5 NMI SFI1 ZBTB16	35 interacting genes: APC APLP1 ARFIP2 BARD1 C3orf62 CCDC33 CDCA7L CDK2 CDKN1A CEP126 CEP44 DEUP1 EP300 FAM118B GCSH HAP1 HGS HTT ICA1 IKZF3 JADE2 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 PCM1 PRMT5 SMARCE1 TADA3 TAF1D TP53 VIM
Entrez ID		2653	84289
HPRD ID		01998	16348
Ensembl ID		ENSG00000140905	ENSG00000168395
Uniprot IDs		P23434	A0A1B0GW41 Q8WYH8
PDB IDs			3C6W 5ME8 5MTO
Enriched GO Terms of Interacting Partners?
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