IST1 and SPAST

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down)

		IST1	SPAST
Description		IST1 factor associated with ESCRT-III	spastin
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GO Annotations	Cellular Component	Chromatin Extracellular Region Nuclear Envelope Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Midbody Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Flemming Body	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Protein Localization Abscission Protein Transport Viral Release From Host Cell Multivesicular Body Assembly Neutrophil Degranulation Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis ESCRT III Complex Disassembly	Mitotic Cytokinesis Microtubule Bundle Formation ER To Golgi Vesicle-mediated Transport Axonogenesis Anterograde Axonal Transport Metabolic Process Exit From Mitosis Axonal Transport Of Mitochondrion Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Nuclear Envelope Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cytoskeleton-dependent Cytokinesis Membrane Fission
Pathways		Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III	Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Blood protein levels ( 28240269) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		5 interacting genes: APEH ATXN1 CAPN7 SPAST UBQLN1	4 interacting genes: CHMP1B IST1 RTN1 SSNA1
Entrez ID		9798	6683
HPRD ID		13784	05044
Ensembl ID		ENSG00000182149	ENSG00000021574
Uniprot IDs		B4DXC9 P53990	E5KRP5 E5KRP6 Q9UBP0
PDB IDs		3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G	3EAB 3VFD 5Z6Q 5Z6R
Enriched GO Terms of Interacting Partners?
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