KMT2B and TSC22D1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		KMT2B	TSC22D1
Description		lysine methyltransferase 2B	TSC22 domain family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Ovarian Follicle Development Memory Oocyte Differentiation Gene Silencing Ovulation Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Methylation Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Rosacea symptom severity ( 29771307)
Interacting Genes		25 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TSC22D1 ZNF512B	50 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GTF2F2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1
Entrez ID		9757	8848
HPRD ID		06017	07414
Ensembl ID		ENSG00000272333	ENSG00000102804
Uniprot IDs		Q9UMN6	A0A024RDV8 A0A087X0H8 A8K3Y6 Q15714
PDB IDs		3UVM 4ERZ 4PZI
Enriched GO Terms of Interacting Partners?
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