KMT2B and ATP1B1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		KMT2B	ATP1B1
Description		lysine methyltransferase 2B	ATPase Na+/K+ transporting subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Cell Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	ATPase Activator Activity Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Protein C-terminus Binding Drug Binding ATPase Activity Cation-transporting ATPase Activity Protein Kinase Binding MHC Class II Protein Complex Binding Potassium Ion Binding Sodium Ion Binding Protein Heterodimerization Activity ATPase Binding
	Biological Process	Ovarian Follicle Development Memory Oocyte Differentiation Gene Silencing Ovulation Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Methylation Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation	Response To Hypoxia Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft ATP Metabolic Process Protein Stabilization Leukocyte Migration Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cation Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of Potassium Ion Import Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Basigin interactions Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Electrocardiographic traits ( 25055868) Fuchs's corneal dystrophy ( 28358029) Mitochondrial DNA levels ( 25240745) QT interval ( 23166209 29213071 24952745 19305409) Rosacea symptom severity ( 29771307)
Interacting Genes		25 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TSC22D1 ZNF512B	26 interacting genes: BACE1 BARD1 BRCA1 CD84 CREG1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HCRTR1 KMT2B LRIF1 NDRG2 PAXIP1 PRRX1 PSME1 SERPINC1 THOC1 TM4SF1 TRIM14 TRMT2A TSC22D2 USP4
Entrez ID		9757	481
HPRD ID		06017	01663
Ensembl ID		ENSG00000272333	ENSG00000143153
Uniprot IDs		Q9UMN6	A3KLL5 P05026
PDB IDs		3UVM 4ERZ 4PZI
Enriched GO Terms of Interacting Partners?
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